Use an f-stop no wider/larger than f/16 to get all or most of the main subject in focus.

Ladybug on a daisy. Photograph by Yoann Ducamp.

Macro Photo Tip: As a general rule you should use an f-stop no wider/larger than f/16 to get all or most of the main subject in focus. If you are photographing a subject that can’t be arranged more or less on the same plane, you will have to decide which parts of it you want in focus.

source: photography.nationalgeographic.com/photography/photo-tips/macro-photo-tips/#/ladybug-macro_26203_600x450.jpg

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